Abstract
Biofilm, a complex collection of bacterial colonies, presents many challenges to current drugs targeting bacterial infections (Barzegari et al., 2020). Resveratrol, a compound found in grape plants, has reduced biofilm formation and interfered with quorum sensing mediated behaviors in several bacterial species (Vestergaard & Ingmer, 2019). In Vibrio harveyi, biofilm formation is regulated by quorum sensing, which is a bacterial communication system (Frederix & Downie, 2011). Thus, we propose to study the inhibitory effects of resveratrol on the mechanisms of quorum sensing in Vibrio harveyi by observing biofilm formation and bioluminescence. Conclusions were made regarding BB120 (wild-type) and BB721 (constitutively glowing mutant). Our result suggests that resveratrol is a promising quorum sensing inhibitor within a specific concentration range, as it didn’t kill the bacteria and yet disabled quorum-sensing-associated phenotypes.
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