Biofilms are collections of bacterial cells that create a protective protein matrix around themselves and attach to a surface such as a medical implant. Resveratrol is an extract from grapes and other plants that has been used in previous studies to inhibit biofilm formation. This research project used resveratrol to prevent biofilm growth by the bacterial strain V. harveyi in hopes of discovering the mechanism by which resveratrol is able to inhibit biofilm formation. Two strains of V. harveyi, BB120 and BB170, were used in these experiments. Our studies found that resveratrol decreased biofilm formation in both strains while decreasing cell viability in BB120 and allowing BB170 to remain completely viable. These results suggest that resveratrol inhibits the mechanisms that both strains use to form biofilms and also has an impact on some aspect of the BB120 strain that is not present in BB170. These findings present resveratrol as an effective biofilm inhibitor and offer hope that resveratrol could be harnessed into a treatment for biofilm infections.
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